国产午夜在线观看不卡av,卡一卡二国产在线观看

Release date：2018-11-26

Allergy

[IF:6.048]

Endotypes of pollen-food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification
DOI: 10.1111/all.12888
Abstract:
Background: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers,severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens.
Methods: We examined 1271 Italian children (age 4–18 years) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts. IgE to panallergens Phl p 12 (profilin), Bet v 1 (PR-10), and Pru p 3 (nsLTP) were tested by ImmunoCAP FEIA. An unsupervised hierarchical agglomerative clustering method was applied within PFS population.
Results: PFS was observed in 300/1271 children (24%). Cluster analysis identified five PFS endotypes linked to panallergen IgE sensitization: (i) cosensitization to≥2 panallergens (‘multi-panallergen PFS’); (ii–iv) sensitization to either profilin,or nsLTP, or PR-10 (‘mono-panallergen PFS’); (v) no sensitization to panallergens (‘no-panallergen PFS’). These endotypes showed peculiar characteristics: (i)‘multi-panallergen PFS’: severe disease with frequent allergic comorbidities and multiple offending foods; (ii) ‘profilin PFS’: oral allergy syndrome (OAS) triggered by Cucurbitaceae; (iii) ‘LTP PFS’: living in Southern Italy, OAS triggered by hazelnut and peanut; (iv) ‘PR-10 PFS’: OAS triggered by Rosaceae; and (v) ‘no-panallergen PFS’: mild disease and OAS triggered by kiwifruit.
Conclusions: In a Mediterranean country characterized by multiple pollen exposures, PFS is a complex and frequent complication of childhood SAR, with five distinct endotypes marked by peculiar profiles of IgE sensitization to panallergens. Prospective studies in cohorts of patients with PFS are now required to test whether this novel classification may be useful for diagnostic and therapeutic purposes in the clinical practice.
First Author:
C. Mastrorilli
Correspondence:
Matricardi, Department of Pediatric Pneumology and Immunology, Charite Medical University, Augustenburger Platz
All Authors:
C. Mastrorilli, S. Tripodi, C. Caffarelli1, S. Perna, A. Di Rienzo-Businco, I. Sfika, R. Asero, A. Dondi, A. Bianchi, C. Povesi Dascola, G. Ricci, F. Cipriani, N. Maiello, M. Miraglia Del Giudice, T. Frediani, S. Frediani, F. Macr?, C. Pistoletti, I. Dello Iacono, M. F. Patria,E. Varin, D. Peroni, P. Comberiati, L. Chini, V. Moschese, S. Lucarelli, R. Bernardini,G. Pingitore, U. Pelosi, R. Olcese, M. Moretti, A. Cirisano, D. Faggian, A. Travaglini,M. Plebani, M. C. Verga, M. Calvani, P. Giordani&P. M.

2018-11-07 Article

Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd. Copyright HZKC Technical support 浙ICP備14005341號(hào) （浙）-非經(jīng)營(yíng)性-2019-0050

Address: Rm.201-209, Bldg.2, No.568 Binkang Rd., Binjiang Dist. Tel: 0571-87968248-805 Website:www.carnationgroup.cn

Official WeChat

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合久久综合久久

杭州浙大迪迅生物基因工程有限公司

Release date：2018-11-26

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合 久久 综合 久久

杭州浙大迪迅生物基因工程有限公司

Release date：2018-11-26

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合久久综合久久